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| Product Name | (S)-Glycyl-H-1152 (hydrochloride) |
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| Description | Purity >98%. Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. 2 3 Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits Ca2+ /calmodulin-dependent kinase type II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 µM, respectively) as well as PKA or PKC (IC50 = 10 µM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM). |
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| Size | n/a |
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| Applications | n/a |
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| Other Names | 2-amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]-ethanone, dihydrochloride, Rho Kinase Inhibitor IV |
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| Gene, Accession, CAS # | CAS: 913844-45-8 |
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| Catalog # | LS-H5679 |
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| Order / More Info | (S)-Glycyl-H-1152 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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