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| Product Name | SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) protein (His tag) |
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| Description | Small Ubiquitin-like Modifier 1 (SUMO1), also known as Sentrin, UBL1, and SMT3C, is synthesized as a 101 amino acid (aa) propeptide with a predicted molecular weight of 11. 5 kDa. Human SUMO1 is the most unique of the four identified SUMO proteins and shares only 44% , 47%, and 41% aa sequence identity with SUMO2, SUMO3, and SUMO4, respectively. In contrast, human SUMO1 shares 100% aa sequence identity with the mouse ortholog. SUMOs are a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed SUMOylation. All SUMO proteins share a conserved ubiquitin domain and a C-terminal diglycine cleavage/attachment site. Following cleavage of a four aa C-terminal prosegment, the C-terminal glycine residue of SUMO1 is enzymatically attached to a lysine residue on a target protein. In humans, SUMO1 is conjugated to a variety of molecules in the presence of the SAE1/UBA2 SUMO-activating (E1) enzyme and the UBE2I/Ubc9 SUMO-conjugating (E2) enzyme. In yeast, the SUMO-activating (E1) enzyme is Aos1/Uba2p. SUMOylation can occur without the requirement of a specific SUMO ligase (E3), where SUMO1 is transferred directly from UBE2I/Ubc9 to specific substrates. In Alzheimer's disease models SUMO1 has been shown to influence the generation of amyloid-beta peptide by promoting the accumulation of BACE-1. Covalent modification of PTEN by SUMO1 is thought to regulate tumorigenesis by retaining PTEN at the plasma membrane, an effect that suppresses PI 3-Kinase/Akt-dependent tumor growth. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | CG4494|Dm0342|DmSUMO-1|DmSmt3|Dmel\\CG4494|Dmsmt3|SMT3|SUMO|Smt3|Sumo|anon-EST:Posey240|dSmt3|dsmt3|l(2)04493|l(2)SH0182|l(2)SH2 0182|sumo|SUMO1|sumo-1|sumo1|4921531N22Rik|AI789753|AU040360|DAP-1|Gkap|DAP1|GMP1|OFC10|PIC1|SENP2|SMT3C|SMT3H3|UBL1|ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1|ATSUMO1|F10M23.180|F10M23_180|SMALL UBIQUITIN-LIKE MODIFIER 1|SUM1|SUMO 1|small ubiquitin-like modifier 1|pigSUMO1|SENTRIN|SMTP3|SUMO-1|Smt3C|Ubl1|hm:zeh0670|wu:fb74c02|wu:fd12c02|zgc:65934|zgc:85634 |
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| Gene, Accession, CAS # | Gene ID: 7341 |
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| Catalog # | ABIN2745844 |
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| Order / More Info | SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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