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| Product Name | Recombinant Rat Suppressor of cytokine signaling 3 |
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| Description | 1-225. Full-length. MW: 40.79kD. Purity >90% as determined by SDS-PAGE. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses f |
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| Size | 0.01 mg (Yeast), 0.01 mg (E-Coli), 0.1 mg (Yeast), 0.1 mg (E-Coli), 0.2 mg (Yeast) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Cytokine-inducible SH2 protein 3] |
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| Gene, Accession, CAS # | Socs3, Gene ID: 89829, Accession: NP_446017.1 |
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| Catalog # | MBS1169806 |
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| Order / More Info | Recombinant Rat Suppressor of cytokine signaling 3 from MYBIOSOURCE INC. |
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| Product Specific References | Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo.Mao Y., Ling P.R., Fitzgibbons T.P., McCowen K.C., Frick G.P., Bistrian B.R., Smith R.J.Endocrinology 140:5505-5515(1999) le Cam A. Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor.Eyckerman S., Broekaert D., Verhee A., Vandekerckhove J., Tavernier J.FEBS Lett. 486:33-37(2000) |
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