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| Product Name | Recombinant Human DNA-(apurinic or apyrimidinic site) lyase |
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| Description | 32-318aa; Full Length. MW: 36.3kD. Purity >90% as determined by SDS-PAGE. Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic inc |
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| Size | 0.01 mg (Yeast), 0.01 mg (E-Coli), 0.05 mg (Yeast), 0.05 mg (E-Coli), 0.1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1] |
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| Gene, Accession, CAS # | APEX1, Gene ID: 328, Accession: NP_001231178.1 |
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| Catalog # | MBS717553 |
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| Price | |
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| Order / More Info | Recombinant Human DNA-(apurinic or apyrimidinic site) lyase from MYBIOSOURCE INC. |
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| Product Specific References | Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) |
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