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| Product Name | Abl Kinase, Active, Recombinant, Human, His-Tag |
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| Description | Purified (~75%). The c-ABL proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-ABL proto- oncogene undergoes a chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) as a result of the fustion of c-ABL sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/ABL mRNA encoding activated ABL protein tyrosine kinase. Source: Recombinant corresponding to aa248-531 from human Abelson murine leukemia viral oncogene homolog 1, fused to His-tag at N-terminal, expressed in a Baculovirus-infected Sf9 cell expression system. Molecular Weight: ~33kD Applications: Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Abl Kinase, Active, Recombinant, Human, His-Tag (ABL, Tyrosine-protein Kinase ABL1, Abelson Murine Leukemia Viral Oncogene Homolog 1, c-Abl, Proto-oncogene c-Abl, p150, ABL1, JTK7) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 137251 |
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| Order / More Info | Abl Kinase, Active, Recombinant, Human, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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