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| Product Name | EphA7, Recombinant, Human, Fc Chimera |
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| Description | Purity ~95% (SDS-PAGE). EphA7, also known as Mdk1, Hek11, Ehk3, Ebk, and Cek11, is a 115-120kD glycosylated member of the Eph family of transmembrane receptor tyrosine kinases. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. EphA7 preferentially binds to and is activated by Ephrin-A1, -A2, -A3, -A4, and -A5. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. The 532aa extracellular domain (ECD) of human EphA7 contains an N-terminal Ephrin binding region, a cysteine-rich region, and two fibronectin type III domains (FnIII). The 421aa cytoplasmic domain contains the tyrosine kinase domain and a sterile alpha motif (SAM). Within the ECD, human EphA7 shares 98% aa sequence identity with mouse and rat EphA7. Alternate splicing generates secreted isoforms of human EphA7 that are truncated either before or following the first FnIII do |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | EphA7, Recombinant, Human, Fc Chimera (Ephrin Type-A Receptor 7, EPH Homology Kinase 3, EHK-3, EPH-like Kinase 11, EK11, hEK11, EHK3, HEK11) |
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| Gene, Accession, CAS # | Accession: NP_004431 |
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| Catalog # | E3363-07G |
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| Order / More Info | EphA7, Recombinant, Human, Fc Chimera from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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