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| Product Name | EphA3, Recombinant, Human, Fc Chimera |
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| Description | Purity ~95% (SDS-PAGE). EphA3, also known as Cek4, Mek4, Hek, Tyro4, and Hek4, is a 135kD glycosylated member of the transmembrane Eph receptor tyrosine kinase family. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. EphA3 preferentially binds to Ephrin-A5. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression (1, 2). The 521aa extracellular domain (ECD) of human EphA3 contains an N-terminal Ephrin binding region, a cysteine-rich region, and two fibronectin type II domains. The 418 aa cytoplasmic domain contains the tyrosine kinase domain and a sterile alpha motif (SAM) (3, 4). Within the ECD, human EphA3 shares 96% aa sequence identity with mouse and rat EphA3. Alternate splicing generates a secreted isoform that consists of nearly the entire ECD. EphA3 is expressed in the developing forebrain, retinal axons, some spinal cord motor |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | EphA3, Recombinant, Human, Fc Chimera (Ephrin Type-A Receptor 3, Tyrosine-protein Kinase Receptor ETK1, HEK, EPH-like Kinase 4, HEK4, EK4, Tyrosine-protein Kinase TYRO4, ETK, ETK1, HEK, TYRO4) |
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| Gene, Accession, CAS # | Accession: NP_005224 |
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| Catalog # | E3365-05 |
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| Order / More Info | EphA3, Recombinant, Human, Fc Chimera from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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