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| Product Name | OTUB1, Recombinant, Human, aa2-201, GST-Tag (Ubiquitin Thioesterase OTUB1) |
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| Description | Purity ~90% (SDS-PAGE). Hydrolase that can specifically rove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of roving NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin. Plays a key no |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Deubiquitinating enzyme OTUB1,OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, hOTU1 Ubiquitin-specific-processing protease OTUB1 |
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| Gene, Accession, CAS # | SwissProt: Q96FW1 |
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| Catalog # | 374570 |
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| Order / More Info | OTUB1, Recombinant, Human, aa2-201, GST-Tag (Ubiquitin Thioesterase OTUB1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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