| 产品详情 |
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| Antigenic Specificity | Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (aa 1-331) |
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| Clone | S84-37 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | alkaline phosphatase (AP) conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry (ICC),Immunofluorescence (IF),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Laforin, also known as Lafora PTPase, is a dual specificity protein phosphatase. Laforin is involved in the control of glycogen metabolism, specifically in preventing the formation of poorly branched glycogen molecules (polyglucosans). Laforin forms a complex with NHLRC1/malin and HSP70 that suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Laforin is expressed in heart, skeletal muscle, kidney, pancreas and brain. Defective Laforin is linked to progressive myoclonic epilepsy type 2 (EPM2).Cellular Localization: Endoplasmic reticulum |
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| Immunogen | Fusion protein amino acids 1-331 (full-length) of human Laforin. Rat: 90% identity (296/327 amino acids identical). Mouse: 89% identity (295/327 amino acids identical) |
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| Other Names | TG-B|Tg(TcraK,TcrbK)TG-BFlv|EPM2|MELF|laforin |
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| Gene, Accession # | Gene ID: 7957 |
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| Catalog # | ABIN1741368 |
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| Price | |
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| Order / More Info | Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) (EPM2A) (aa 1-331) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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