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| Product Name | Recombinant Human Methionine aminopeptidase 2 (METAP2) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 54.8kDa. Full Length of Mature Protein: 2-478aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Cotranslationally roves the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Initiation factor 2-associated 67KDA glycoprotein |
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| Gene, Accession, CAS # | METAP2, UniProt: P50579 |
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| Catalog # | RPC24813 |
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| Order / More Info | Recombinant Human Methionine aminopeptidase 2 (METAP2) from BIOMATIK |
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| Product Specific References | n/a |
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