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| Product Name | Mouse NTF4 / Neurotrophin 4 Protein (Recombinant) |
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| Description | Purity >95% by SDS-PAGE, MW: 14.0 kDa (SDS-PAGE). Neurotrophin-4 (NT-4) is a small secreted cytokine, and belongs to the Neurotrophin (NT) family, which also includes Brain Derived Neurotropic Factor (BDNF), Nerve Growth Factor (NGF), and NT-3. NT family members are all derived from similar sized protein precursors, composed of N-terminal propeptides and C-terminal mature domains, which are separated by posttranslational proteolytic cleavage. NT-4 (along with NT-3) is foundin the brains of mammals. In vivo, NT-4 binds to the common receptor, p75NTR, and a tyrosine kinase receptor, TrkB. The heterotrimeric complex activates the NF-kappaB transcription factor. NT-4 is essential for the differentiation and wiring regulation of the central and peripheral nervous systems during development, and is related to important diseases including Alzheimer's.Recombinant mouse Neurotrophin-4 (rmNT-4) produced in E. coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chainsof 131 amino acids. A fully biologically active molecule, rmNT-4 has a molecular mass of 14.0kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NTF4, GLC1O, GLC10, Neurotrophic factor 5, NT-4, Neurotrophic factor 4, Neurotrophin-4, Neurotrophin-4 precursor, NT-5, NT4, NT5, NTF5, Neurotrophin 4, Neurotrophin-5, Neutrophic factor 4, NT-4/5 |
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| Gene, Accession, CAS # | NTF4, Gene ID: 4909 |
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| Catalog # | LS-G27239 |
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| Order / More Info | Mouse NTF4 / Neurotrophin 4 Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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