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| Product Name | Recombinant Mouse c-MET / HGFR Protein (Fc tag) (Fc tag) |
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| Description | MW: 153,549 Da. Purity >92 % as determined by SDS-PAGE. Background: Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aber |
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| Size | 0.1 mg, 0.2 mg |
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| Concentration | n/a |
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| Applications | The recombinant mouse Met/Fc chimera is a disulfide-linked homodimer of the Met which is a heterodimer composed of the proteolytically cleaved alpha and beta subunits. Each alpha and beta together with the C-terminal Fc tag consists of 1146 amino acids and has a predicted molecular mass of 128 (alpha =32 + Fc tagged beta=96) kDa. The apparent molecular mass of the rm MET/Fc heterodimer thus is approximately 43 kDa and 115-120 kDa respectively in SDS-PAGE under reducing conditions due to glycosylation. |
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| Other Names | [AI838057, HGF, HGFR, Par4, c-Met] |
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| Gene, Accession, CAS # | c-MET / HGFR, Gene ID: 17295, Accession: NP_032617.2 |
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| Catalog # | MBS2546883 |
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| Order / More Info | Recombinant Mouse c-MET / HGFR Protein (Fc tag) (Fc tag) from MYBIOSOURCE INC. |
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| Product Specific References | n/a |
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