| 产品详情 |
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| Antigenic Specificity | CD117 (c-Kit) |
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| Clone | 2B8 |
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| Host Species | Rat |
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| Reactive Species | mouse, porcine |
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| Isotype | IgG2b, kappa |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 0.5 µg/test, Immunoprecipitation: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD117 (c-Kit) Monoclonal Antibody (2B8), eBioscience™. c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation |
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| Immunogen | n/a |
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| Other Names | C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, ckit |
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| Gene, Accession # | Entrez: 16590, 396810; Uniprot: P05532, Q2HWD6 |
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| Catalog # | 14-1171-82 |
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| Price | |
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| Order / More Info | CD117 (c-Kit) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 15983065, 16943245, 17030619, 17702899, 18461720, 19028500, 19109220, 19181844, 19395555, 19593793, 19759338, 19956687, 20231424, 20980679, 21038084, 21134573, 21270411, 21282380, 21300914, 21515822, 21659540, 21813452, 21924496, 21948176, 21963833, 21990371, 22231305, 22531781, 22547652, 22573620, 22628281, 22854708, 23280653, 23290520, 23333753, 23396050, 23505428, 23589569, 23780386, 23795291, 23924635, 24028396, 24046360, 24416383, 24812670, 25025394, 25225459, 25245760, 25555218, 25641176, 25692908, 25917428, 26416744, 26465397, 26474484, 26601269, 26811463, 26830229, 26923823, 26974155, 27099134, 27106930, 27123834, 28272478, 28589939, 28963568, 29555020 |
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