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| Product Name | Recombinant Human Gem-associated protein 7 (GEMIN7) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 41.5kDa. Full Length: 1-131aa. N-terminal GST-tagged. Homo sapiens (Human). The SMN complex plays a catalyst role in the assbly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assbly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assbly of core snRNPs and their transport to the nucleus. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | SIP3 |
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| Gene, Accession, CAS # | GEMIN7, UniProt: Q9H840 |
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| Catalog # | RPC23542 |
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| Order / More Info | Recombinant Human Gem-associated protein 7 (GEMIN7) from BIOMATIK |
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| Product Specific References | n/a |
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