| 产品详情 |
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| Product Name | Recombinant Human Asporin (ASPN) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 55.7kDa. Full Length of Mature Protein: 33-380aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Periodontal ligament-associated protein 1; Short name:PLAP-1 |
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| Gene, Accession, CAS # | ASPN, UniProt: Q9BXN1 |
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| Catalog # | RPC20946 |
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| Price | |
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| Order / More Info | Recombinant Human Asporin (ASPN) from BIOMATIK |
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| Product Specific References | n/a |
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