| 产品详情 |
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| Product Name | Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit alpha |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 31.8kDa. Full Length: 1-136aa. N-terminal 6xHis-SUMO-tagged. Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma). Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the Cytoplasmic domain tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha-2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Aggretin alpha chain; Rhodoaggretin subunit alpha |
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| Gene, Accession, CAS # | UniProt: Q9I841 |
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| Catalog # | RPC20337 |
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| Order / More Info | Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit alpha from BIOMATIK |
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| Product Specific References | n/a |
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