| 产品详情 |
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| Product Name | Mevastatin |
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| Description | Purity >97%. HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the 'statin'class of cholesterol-lowering drugs. Mevastatin is a HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. It inhibits HMG-CoA reductase in a reversible and competitive manner with a Ki value of 1 nM for the open ring acid form of the molecule. During a 24 week study period, a dose of 30 mg/day mevastatin reduced plasma LDL-cholesterol approximately 29% in patients with familial hypercholesterolemia. Mevastatin also suppresses TNF-induced NF- kappa B activation (IC50 = ~17 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2S-methyl-(1S,2,3,7S,8S,8aR)-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2-H-pyran-2-yl]ethyl]-1-naphthalenyl ester-butanoic acid, Compactin, CS500, L637312, ML236B, NSC281245, StatinI |
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| Gene, Accession, CAS # | CAS: 73573-88-3 |
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| Catalog # | LS-H41 |
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| Price | |
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| Order / More Info | Mevastatin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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