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| Product Name | Recombinant Sheep Interleukin-12 subunit beta (IL12B) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 38.5kDa. Full Length of Mature Protein: 23-327aa. N-terminal 6xHis-tagged. Ovis aries (Sheep). Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates mory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Cytotoxic lymphocyte maturation factor 40KDA subunit; CLMF p40IL-12 subunit p40 |
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| Gene, Accession, CAS # | IL12B, UniProt: P68220 |
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| Catalog # | RPC21506 |
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| Price | |
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| Order / More Info | Recombinant Sheep Interleukin-12 subunit beta (IL12B) from BIOMATIK |
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| Product Specific References | n/a |
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