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| Antigenic Specificity | Disrupted in Schizophrenia 1 (DISC1) (aa 600-650) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > microtubule organizing center > centrosome. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Note: Colocalizes with PCNT at the centrosome. Colocalizes with NDEL1 in the perinuclear region and the centrosome. Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Tissue specificity: Expressed in granule cell precursors within the dentate migratory stream during the first week of postnatal life and in differentiated granule cells of the hippocampus (at protein level). Expressed in dentate gyrus, hippocampus and in the olfactory bulb. Synonyms: Disrupted in schizophrenia 1 homolog |
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| Immunogen | A synthetic peptide from aa region 600-650 of mouse DISC1 conjugated to an immunogenic carrier protein was used as the antigen. |
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| Other Names | DISC1|C1orf136|SCZD9 |
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| Gene, Accession # | Gene ID: 244667 |
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| Catalog # | ABIN1842073 |
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| Price | |
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| Order / More Info | Disrupted in Schizophrenia 1 (DISC1) (aa 600-650) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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