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| Antigenic Specificity | Disrupted in Schizophrenia 1 (DISC1) (aa 74-91), (N-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DISC1(Disrupted in Schizophrenia 1), is a protein that is encoded by the DISC1 gene in humans. Ma et al.(2002) determined that the mouse Disc1 gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al.(2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al.(2005) showed that DISC1 interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human DISC1(74-91aa EESHHSESRARQCGLDSR). |
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| Other Names | DISC1|C1orf136|SCZD9 |
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| Gene, Accession # | Gene ID: 27185 |
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| Catalog # | ABIN1673508 |
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| Price | |
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| Order / More Info | Disrupted in Schizophrenia 1 (DISC1) (aa 74-91), (N-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 16293762, 12506198, 12504857 |
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