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| Product Name | Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 28.2kDa. Full Length: 1-213aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Protein G7; pVHL |
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| Gene, Accession, CAS # | VHL, UniProt: P40337 |
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| Catalog # | RPC22221 |
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| Order / More Info | Recombinant Human Von Hippel-Lindau disease tumor suppressor (VHL) from BIOMATIK |
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| Product Specific References | n/a |
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