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| Product Name | Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (AA 32-266) (Active) protein |
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| Description | Dickkopf related protein 1 (DKK1) is a chemokine that belongs to the DKK protein family, which alsoincludes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. It is one of the most up-regulated genes during androgen-potentiated balding, with DKK-1 messenger RNA up-regulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing bodies against DKK-1 reverses DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate, a metabolite of ascorbatein vitro. DKK1 promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK1 not only functions as a head inducer during development, but also regulates joint remodeling and bone formation, which indicate sits role in the pathogenesis of rheumatoid arthritis and multiple myeloma.Synonyms: DKK-1,Human |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | dkk|dkk-1|xdkk1|Xdkk-1|Dickkopf1|dickkopf-1|dkk1|mdkk-1|DKK-1|SK|dkk1-A|CT34|SGY|SGY-1|SGY1|AI414495|Soggy|mSgy |
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| Gene, Accession, CAS # | Gene ID: 22943 |
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| Catalog # | ABIN2017735 |
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| Order / More Info | Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (AA 32-266) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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