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| Product Name | Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (Active) protein |
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| Description | DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/betacatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/betacatenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Alternative Names: Dickkopf-related protein-1 protein, DKK 1, Dickkopt-1 protein, SK protein, DKK-1 protein, DKK-1, DKK-1 protein, DKK 1 protein, DKK1 |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | dkk|dkk-1|xdkk1|Xdkk-1|Dickkopf1|dickkopf-1|dkk1|mdkk-1|DKK-1|SK|dkk1-A|CT34|SGY|SGY-1|SGY1|AI414495|Soggy|mSgy |
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| Gene, Accession, CAS # | Gene ID: 22943 |
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| Catalog # | ABIN935316 |
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| Order / More Info | Dickkopf Homolog 1 (Xenopus Laevis) (DKK1) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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