| 产品详情 |
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| Product Name | Linsitinib |
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| Description | Purity >98%. The binding of insulin-like growth factor 1 (IGF-1) to the IGF-1 receptor (IGF-1R) promotes cell growth while inhibiting apoptotic pathways. Overexpression of IGF-1R is found in certain solid tumors and hematologic neoplasias. However, insulin receptor (InsR) signaling can compensate for IGF-1R inhibition. Linsitinib is a dual inhibitor of IGF-1R and InsR kinases (IC50 s = 35 and 75 nM, respectively). It also inhibits InsR-related receptor (IC50 = 75 nM) but is without effect (IC50 > 10 µM) against a large panel of other kinases. Linsitinib inhibits proliferation of a variety of tumor cell lines in vitro and has antitumor efficacy in an IGF-1R-driven xenograft mouse model when administered orally. A rapid, non-invasive method to predict the pharmacodynamic response to linsitinib has been reported. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | cis -3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol, OSI-906 |
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| Gene, Accession, CAS # | CAS: 867160-71-2 |
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| Catalog # | LS-H8486 |
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| Price | |
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| Order / More Info | Linsitinib from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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