| 产品详情 |
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| Product Name | BRD-K4477 |
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| Description | Purity >98%. BRD-K4477, also known as functional hits 1 (FH1), is a small molecule promotor of hepatocyte differentiation in vitro . It induces maturation of hepatocyte-like cells (iHeps) to a more adult-like liver phenotype in a concentration-dependent manner. BRD-K4477 increases albumin secretion and promotes hepatocyte morphologies including polygonal cell shapes, visible nuclei, and formation of bile canaliculi in iHeps. It also increases expression of ABCB11 and bile-salt export pump (BSEP) mRNA as well as activity of the mature cytochrome P450 (CYP) isoforms CYP3A and CYP2A6 in iHeps. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N,N'-(methylenedi-4,1-phenylene)bis -acetamide, NSC 12407, FH1, Functional Hits 1, Methylenebis-4,4'-acetanilide |
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| Gene, Accession, CAS # | CAS: 299257 |
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| Catalog # | LS-H6897 |
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| Order / More Info | BRD-K4477 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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